Product Data Sheet
TIY-7
Catalog No. A35008
TIY-7 is a selective and orally active inhibitor of tropomyosin receptor kinases (TRKs). It demonstrates potent enzyme inhibition with IC50 values of 2.9 nM for TRKA and as low as 0.2 nM for TRKCG696A, showcasing its efficacy against various TRK mutations. TIY-7 exhibits significant anti-tumor activity in mouse xenograft models, making it a valuable tool for research in cancer biology and targeted therapy development.
Chemical Information
| Catalog Num | A35008 |
|---|---|
| M. Wt | 446.40 |
| Formula | C21H18F4N6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2846435-83-2 |
| Synonyms | |
| SMILES | FC1=CC=C(C([C@H]2CCCN2C3=NC4=C(C=NN4C=C3)C5=CNN=C5)=C1)OCC(F)(F)F |
Biological Activity
| Description | TIY-7 is a selective and orally active inhibitor of tropomyosin receptor kinases (TRKs). It demonstrates potent enzyme inhibition with IC50 values of 2.9 nM for TRKA and as low as 0.2 nM for TRKCG696A, showcasing its efficacy against various TRK mutations. TIY-7 exhibits significant anti-tumor activity in mouse xenograft models, making it a valuable tool for research in cancer biology and targeted therapy development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
