Product Data Sheet
Type II TRK inhibitor 1
Catalog No. A35031
Type II TRK inhibitor 1 is a selective inhibitor targeting TRK fusion proteins and wild-type TRK, demonstrating potent anti-proliferative effects in Ba/F3 cell lines that express the CD74-TRKAG667C and ETV6-TRKCG696C variants, with IC50 values of 6 nM and 1.7 nM, respectively. Additionally, this compound functions as a click chemistry reagent, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling its application in bioconjugation and related chemical biology research.
Chemical Information
| Catalog Num | A35031 |
|---|---|
| M. Wt | 670.68 |
| Formula | C35H33F3N8O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2937543-72-9 |
| Synonyms | |
| SMILES | CN(CCN1)C2=NN3C(C=C2)=NC=C3C#CC4=CC(OCCCCC1=O)=CC(C(NC5=CC(N6C=C(C)N=C6)=CC(C(F)(F)F)=C5)=O)=C4C |
Biological Activity
| Description | Type II TRK inhibitor 1 is a selective inhibitor targeting TRK fusion proteins and wild-type TRK, demonstrating potent anti-proliferative effects in Ba/F3 cell lines that express the CD74-TRKAG667C and ETV6-TRKCG696C variants, with IC50 values of 6 nM and 1.7 nM, respectively. Additionally, this compound functions as a click chemistry reagent, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling its application in bioconjugation and related chemical biology research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
