Product Data Sheet
NMS-P626
Catalog No. A35034
NMS-P626 is a potent inhibitor of the tropomyosin receptor kinase A (TRKA), TRKB, and TRKC, demonstrating IC50 values of 8 nM, 7 nM, and 3 nM, respectively. This compound effectively inhibits the proliferation of KM12 colorectal cancer cells by suppressing the phosphorylation of TPM3-TRKA and disrupting downstream signaling pathways, with an observed IC50 of 19 nM in these cells. NMS-P626 is valuable for research applications focused on colorectal cancer and related signaling mechanisms.
Chemical Information
| Catalog Num | A35034 |
|---|---|
| M. Wt | 603.68 |
| Formula | C28H35F2N7O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 942471-37-6 |
| Synonyms | |
| SMILES | O=C(C1=C(N[C@@H](COC)C)C=C(N2CCN(C)CC2)C=C1)NC3=NNC4=C3CN(S(C5=CC(F)=CC(F)=C5)(=O)=O)CC4 |
Biological Activity
| Description | NMS-P626 is a potent inhibitor of the tropomyosin receptor kinase A (TRKA), TRKB, and TRKC, demonstrating IC50 values of 8 nM, 7 nM, and 3 nM, respectively. This compound effectively inhibits the proliferation of KM12 colorectal cancer cells by suppressing the phosphorylation of TPM3-TRKA and disrupting downstream signaling pathways, with an observed IC50 of 19 nM in these cells. NMS-P626 is valuable for research applications focused on colorectal cancer and related signaling mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
