Product Data Sheet
ONO-7579
Catalog No. A35038
ONO-7579 is an orally bioavailable inhibitor targeting TRKA, primarily inhibiting its phosphorylation to reduce tumor growth. In studies with colorectal cancer cell line KM12, it exhibits an EC50 of 17.6 ng/g, indicating that this concentration effectively reduces phosphorylated TRKA activity by 50%. ONO-7579 is useful in cancer research, particularly in exploring therapeutic strategies against tumors reliant on TRKA signaling.
Chemical Information
| Catalog Num | A35038 |
|---|---|
| M. Wt | 578.95 |
| Formula | C24H18ClF3N6O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1622212-25-2 |
| Synonyms | |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1S(=O)(C)=O)NC2=CN=C(OC3=CC=C(C4=CC(Cl)=CN=C4N)C=C3)N=C2 |
Biological Activity
| Description | ONO-7579 is an orally bioavailable inhibitor targeting TRKA, primarily inhibiting its phosphorylation to reduce tumor growth. In studies with colorectal cancer cell line KM12, it exhibits an EC50 of 17.6 ng/g, indicating that this concentration effectively reduces phosphorylated TRKA activity by 50%. ONO-7579 is useful in cancer research, particularly in exploring therapeutic strategies against tumors reliant on TRKA signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
