Product Data Sheet
GNF2133
Catalog No. A35047
GNF2133 is a potent and selective inhibitor of DYRK1A, exhibiting an IC50 of 0.0062 µM for DYRK1A, with minimal activity against GSK3β (>50 µM). This compound has demonstrated significant proliferation potency and efficacy in both rat and human primary β-cells. GNF2133 notably enhances glucose disposal capacity and stimulates insulin secretion, making it a valuable reagent for research into type 1 diabetes.
Chemical Information
| Catalog Num | A35047 |
|---|---|
| M. Wt | 434.53 |
| Formula | C24H30N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2561414-56-8 |
| Synonyms | |
| SMILES | CCN1CCN(CC1)C(NC2=NC=CC(C3=CN(C4=CN=CC=C34)C5CCOCC5)=C2)=O |
Biological Activity
| Description | GNF2133 is a potent and selective inhibitor of DYRK1A, exhibiting an IC50 of 0.0062 µM for DYRK1A, with minimal activity against GSK3β (>50 µM). This compound has demonstrated significant proliferation potency and efficacy in both rat and human primary β-cells. GNF2133 notably enhances glucose disposal capacity and stimulates insulin secretion, making it a valuable reagent for research into type 1 diabetes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
