Product Data Sheet
AO-365/43472821
Catalog No. A35048
AO-365/43472821 is a selective inhibitor of Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), with an IC50 of 0.29 μM, and demonstrates potent inhibition of CLK1 (IC50 = 0.08 μM). This compound has been shown to protect the human neuroblastoma cell line SH-SY5Y from Okadaic acid-induced cytotoxicity. Furthermore, AO-365/43472821 effectively reduces the expression levels of phosphorylated tau (pSer396) and Aβ1-42 proteins, making it a valuable reagent for research related to Alzheimer’s disease.
Chemical Information
| Catalog Num | A35048 |
|---|---|
| M. Wt | 412.42 |
| Formula | C19H16N4O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1081122-55-5 |
| Synonyms | |
| SMILES | COC1=CC=CC=C1OCC2=NN3C(COC4=CC5=C(OCO5)C=C4)=NN=C3S2 |
Biological Activity
| Description | AO-365/43472821 is a selective inhibitor of Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), with an IC50 of 0.29 μM, and demonstrates potent inhibition of CLK1 (IC50 = 0.08 μM). This compound has been shown to protect the human neuroblastoma cell line SH-SY5Y from Okadaic acid-induced cytotoxicity. Furthermore, AO-365/43472821 effectively reduces the expression levels of phosphorylated tau (pSer396) and Aβ1-42 proteins, making it a valuable reagent for research related to Alzheimer’s disease. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
