Product Data Sheet
Protein kinase inhibitor 1 hydrochloride
Catalog No. A35053
Protein Kinase Inhibitor 1 Hydrochloride is a selective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). It demonstrates potent inhibition with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2, alongside a Kd of 9.5 nM for HIPK2. This compound is suitable for studies exploring the role of HIPK family kinases in various signaling pathways and disease models, particularly in cancer research and cellular response to stress.
Chemical Information
| Catalog Num | A35053 |
|---|---|
| M. Wt | 419.89 |
| Formula | C18H18ClN5O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2321337-71-5 |
| Synonyms | |
| SMILES | O=C(NC/1=O)SC1=C\C2=CNC(C(C3=CC=C(N4CCNCC4)N=C3)=C2)=O.[H]Cl |
Biological Activity
| Description | Protein Kinase Inhibitor 1 Hydrochloride is a selective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). It demonstrates potent inhibition with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2, alongside a Kd of 9.5 nM for HIPK2. This compound is suitable for studies exploring the role of HIPK family kinases in various signaling pathways and disease models, particularly in cancer research and cellular response to stress. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
