Product Data Sheet
DYRK2-IN-2
Catalog No. A35081
DYRK2-IN-2 is a selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2), exhibiting an IC50 of 40.3 nM. This compound demonstrates low inhibitory activity against other DYRK family members and CDC-like kinases, making it a specific tool for studying DYRK2. DYRK2-IN-2 effectively inhibits tau protein phosphorylation at Thr212 and exhibits moderate cytotoxicity in HT22 neuronal cells. This reagent is valuable for investigating the role of DYRK2 in cancer biology and neurodegenerative diseases.
Chemical Information
| Catalog Num | A35081 |
|---|---|
| M. Wt | 384.49 |
| Formula | C21H24N2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2416195-65-6 |
| Synonyms | |
| SMILES | COC1=CC2=C(C3=C(C(CO)=CC(OC)=C3)N=C2C=C1)SC[C@H]4CCNC4 |
Biological Activity
| Description | DYRK2-IN-2 is a selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2), exhibiting an IC50 of 40.3 nM. This compound demonstrates low inhibitory activity against other DYRK family members and CDC-like kinases, making it a specific tool for studying DYRK2. DYRK2-IN-2 effectively inhibits tau protein phosphorylation at Thr212 and exhibits moderate cytotoxicity in HT22 neuronal cells. This reagent is valuable for investigating the role of DYRK2 in cancer biology and neurodegenerative diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
