Product Data Sheet
JH-XIV-68-3
Catalog No. A35091
JH-XIV-68-3 is a selective inhibitor of DYRK1A and DYRK1B, targeting these kinases to modulate downstream signaling pathways. This compound exhibits significant antitumor activity in head and neck squamous cell carcinoma (HNSCC) cell lines, making it a valuable tool for cancer research. Its specificity for DYRK1A and DYRK1B is confirmed through biochemical and cellular assays, supporting its potential in therapeutic applications targeting these kinases.
Chemical Information
| Catalog Num | A35091 |
|---|---|
| M. Wt | 468.43 |
| Formula | C22H19F3N8O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2426628-29-5 |
| Synonyms | |
| SMILES | FC(F)(F)C1=NN2C=C1C3=CNC4=NC=C(C=C43)C5=C(C#N)N(C)N=C5CN(C)C(CCC2)=O |
Biological Activity
| Description | JH-XIV-68-3 is a selective inhibitor of DYRK1A and DYRK1B, targeting these kinases to modulate downstream signaling pathways. This compound exhibits significant antitumor activity in head and neck squamous cell carcinoma (HNSCC) cell lines, making it a valuable tool for cancer research. Its specificity for DYRK1A and DYRK1B is confirmed through biochemical and cellular assays, supporting its potential in therapeutic applications targeting these kinases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
