Product Data Sheet
DYRKi
Catalog No. A35103
DYRKi is a selective inhibitor of DYRK1 and DYRK1B, exhibiting IC50 values of 3.7 µM and 90 nM, respectively. This compound effectively antagonizes Hh/Gli signaling pathways, disrupting both SMO-dependent and SMO-independent oncogenic GLI activity in human medulloblastoma cells. DYRKi holds potential for research focused on HH/GLI-associated cancers, providing a valuable tool for elucidating the role of these pathways in tumorigenesis.
Chemical Information
| Catalog Num | A35103 |
|---|---|
| M. Wt | 430.40 |
| Formula | C20H13F3N4O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1640364-04-0 |
| Synonyms | |
| SMILES | O=C(NC1=NC2=CC(C(F)(F)F)=CC=C2N1)C3=CSC(C4=CC=C5OCCC5=C4)=N3 |
Biological Activity
| Description | DYRKi is a selective inhibitor of DYRK1 and DYRK1B, exhibiting IC50 values of 3.7 µM and 90 nM, respectively. This compound effectively antagonizes Hh/Gli signaling pathways, disrupting both SMO-dependent and SMO-independent oncogenic GLI activity in human medulloblastoma cells. DYRKi holds potential for research focused on HH/GLI-associated cancers, providing a valuable tool for elucidating the role of these pathways in tumorigenesis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
