Product Data Sheet
(Z)-Leukadherin-1
Catalog No. A35199
(Z)-Leukadherin-1 is a potent allosteric agonist of CD11b that exhibits oral bioavailability. This compound effectively repolarizes tumor-associated macrophages, diminishes the presence of immunosuppressive myeloid cells within tumors, and enhances the activation of dendritic cells. It serves as a valuable reagent for research in immuno-oncology, exploring mechanisms of immune modulation and macrophage plasticity.
Chemical Information
| Catalog Num | A35199 |
|---|---|
| M. Wt | 421.49 |
| Formula | C22H15NO4S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2055362-72-4 |
| Synonyms | ADH-503 free base |
| SMILES | O=C(O)C1=CC=C(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)/C3=O)O2)C=C1.[(Z)] |
Biological Activity
| Description | (Z)-Leukadherin-1 is a potent allosteric agonist of CD11b that exhibits oral bioavailability. This compound effectively repolarizes tumor-associated macrophages, diminishes the presence of immunosuppressive myeloid cells within tumors, and enhances the activation of dendritic cells. It serves as a valuable reagent for research in immuno-oncology, exploring mechanisms of immune modulation and macrophage plasticity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
