Product Data Sheet
ODN 2216
Catalog No. A35252
ODN 2216 is a selective agonist for human Toll-like receptor 9 (TLR9), known for its role in immune modulation. It stimulates the production of large quantities of interferons, specifically IFN-α and IFN-β, through activation of plasmacytoid dendritic cells (pDCs). ODN 2216 also enhances IL-12 (p40) production by dendritic cells and promotes interferon-gamma (IFN-γ) secretion in peripheral blood mononuclear cells (PBMC) in an indirect manner mediated by IFN-α/β. Additionally, this reagent activates natural killer (NK) cells and supports IFN-γ production in TCR-activated CD4+ T cells, making it valuable for research in immunology and vaccine development.
Chemical Information
| Catalog Num | A35252 |
|---|---|
| M. Wt | 6432.00 |
| Formula | |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 332437-00-0 |
| Synonyms | |
| SMILES | [DNA, d(G-sp-G-sp-G-G-G-A-C-G-A-T-C-G-T-C-G-sp-G-sp-G-sp-G-sp-G-sp-G)] |
Biological Activity
| Description | ODN 2216 is a selective agonist for human Toll-like receptor 9 (TLR9), known for its role in immune modulation. It stimulates the production of large quantities of interferons, specifically IFN-α and IFN-β, through activation of plasmacytoid dendritic cells (pDCs). ODN 2216 also enhances IL-12 (p40) production by dendritic cells and promotes interferon-gamma (IFN-γ) secretion in peripheral blood mononuclear cells (PBMC) in an indirect manner mediated by IFN-α/β. Additionally, this reagent activates natural killer (NK) cells and supports IFN-γ production in TCR-activated CD4+ T cells, making it valuable for research in immunology and vaccine development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
