Product Data Sheet
β-Funaltrexamine hydrochloride
Catalog No. A35301
β-Funaltrexamine hydrochloride is a selective and irreversible antagonist of the μ opioid receptor. This compound demonstrates significant anti-inflammatory and neuroprotective properties by reducing TLR4 signaling, inhibiting cytokine-induced iNOS activation and neuroinflammation, and mitigating neuronal degeneration. Additionally, β-funaltrexamine hydrochloride inhibits NF-κB signaling and chemokine expression in human astrocytes and murine models. It is a valuable tool for research related to neurodegenerative diseases, including stroke.
Chemical Information
| Catalog Num | A35301 |
|---|---|
| M. Wt | 490.98 |
| Formula | C25H31ClN2O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 72786-10-8 |
| Synonyms | β-FNA hydrochloride |
| SMILES | O[C@]1([C@@]2([H])CC3=CC=C4O)[C@@]5(CCN2CC6CC6)C3=C4O[C@@]5([H])[C@H](NC(/C=C/C(OC)=O)=O)CC1.Cl |
Biological Activity
| Description | β-Funaltrexamine hydrochloride is a selective and irreversible antagonist of the μ opioid receptor. This compound demonstrates significant anti-inflammatory and neuroprotective properties by reducing TLR4 signaling, inhibiting cytokine-induced iNOS activation and neuroinflammation, and mitigating neuronal degeneration. Additionally, β-funaltrexamine hydrochloride inhibits NF-κB signaling and chemokine expression in human astrocytes and murine models. It is a valuable tool for research related to neurodegenerative diseases, including stroke. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
