Product Data Sheet
T5342126
Catalog No. A35337
T5342126 is a potent antagonist of Toll-like receptor 4 (TLR4), designed to modulate immune responses. It effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells, with an IC50 of 27.8 μM. Additionally, T5342126 reduces LPS-induced production of pro-inflammatory cytokines, including IL-8, TNF-α, and IL-6 in isolated human whole blood, with IC50 values of 110.5 μM, 315.6 μM, and 318.4 μM, respectively. In vivo, T5342126 (82 mg/kg) decreases ethanol consumption and mitigates microglial activation, as indicated by reduced Iba1 levels, in the central nucleus of the amygdala of ethanol-dependent mice, highlighting its potential in neurological research.
Chemical Information
| Catalog Num | A35337 |
|---|---|
| M. Wt | 457.99 |
| Formula | C25H32ClN3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 956507-49-6 |
| Synonyms | |
| SMILES | OC(COC1=CC=C(OCC)C=C1)CN(CC2=C(C)N(CC3=CC=CC=C3Cl)N=C2C)C |
Biological Activity
| Description | T5342126 is a potent antagonist of Toll-like receptor 4 (TLR4), designed to modulate immune responses. It effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells, with an IC50 of 27.8 μM. Additionally, T5342126 reduces LPS-induced production of pro-inflammatory cytokines, including IL-8, TNF-α, and IL-6 in isolated human whole blood, with IC50 values of 110.5 μM, 315.6 μM, and 318.4 μM, respectively. In vivo, T5342126 (82 mg/kg) decreases ethanol consumption and mitigates microglial activation, as indicated by reduced Iba1 levels, in the central nucleus of the amygdala of ethanol-dependent mice, highlighting its potential in neurological research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
