Product Data Sheet
TLR7/8 agonist 8
Catalog No. A35368
TLR7/8 Agonist 8 is a potent dual agonist for toll-like receptors 7 and 8, demonstrating EC50 values of 27 nM and 12 nM for human TLR7 and TLR8, respectively. This compound enhances antitumor activity in combination with PD-1/PD-L1 blockade, making it a valuable tool for cancer immunotherapy research. Its ability to activate these key immune receptors positions TLR7/8 Agonist 8 as an important reagent in the study of immune modulation and tumor microenvironment interactions.
Chemical Information
| Catalog Num | A35368 |
|---|---|
| M. Wt | 418.53 |
| Formula | C24H30N6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2649170-16-9 |
| Synonyms | |
| SMILES | CCCCNC1=C2N=C(CC3=CC=C(CN4CC5(C4)COC5)C=C3)C=CC2=NC(N)=N1 |
Biological Activity
| Description | TLR7/8 Agonist 8 is a potent dual agonist for toll-like receptors 7 and 8, demonstrating EC50 values of 27 nM and 12 nM for human TLR7 and TLR8, respectively. This compound enhances antitumor activity in combination with PD-1/PD-L1 blockade, making it a valuable tool for cancer immunotherapy research. Its ability to activate these key immune receptors positions TLR7/8 Agonist 8 as an important reagent in the study of immune modulation and tumor microenvironment interactions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
