Product Data Sheet
TLR7 agonist 29
Catalog No. A35418
TLR7 agonist 29 selectively targets Toll-like receptor 7 (TLR7) with an EC50 of 5.2 nM in human cells and 48.2 nM in mouse cells. This compound effectively activates bone marrow-derived macrophages, enhances myeloid cell activity within the tumor microenvironment, and upregulates the expression of key immune markers such as PD-L1, CD86, and IFN-α. TLR7 agonist 29 can also be utilized as a payload in the synthesis of antibody-drug conjugates (ADCs) for targeted cancer therapies.
Chemical Information
| Catalog Num | A35418 |
|---|---|
| M. Wt | 397.47 |
| Formula | C20H27N7O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2275612-76-3 |
| Synonyms | |
| SMILES | NC1=C2C(N(CC3=CN=C(CNC4CCC4)C=C3)C(O)=N2)=NC(OCCCC)=N1 |
Biological Activity
| Description | TLR7 agonist 29 selectively targets Toll-like receptor 7 (TLR7) with an EC50 of 5.2 nM in human cells and 48.2 nM in mouse cells. This compound effectively activates bone marrow-derived macrophages, enhances myeloid cell activity within the tumor microenvironment, and upregulates the expression of key immune markers such as PD-L1, CD86, and IFN-α. TLR7 agonist 29 can also be utilized as a payload in the synthesis of antibody-drug conjugates (ADCs) for targeted cancer therapies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
