Product Data Sheet
IAXO-101 iodide
Catalog No. A35429
IAXO-101 iodide is a specific blocker of TLR4/CD14 signaling. This compound effectively inhibits the innate immune pathway mediated by CD14, demonstrating key biological activities such as enhancing intracortical microelectrode recording capabilities in murine models. Additionally, IAXO-101 iodide has been shown to partially alleviate fetal growth restriction and placental vascular damage, while reducing levels of the inflammatory cytokine TNF-α in pregnant mice with malaria infections. It serves as a valuable research tool for studying gestational malaria and other inflammatory disorders.
Chemical Information
| Catalog Num | A35429 |
|---|---|
| M. Wt | 810.02 |
| Formula | C42H84INO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1202388-64-4 |
| Synonyms | |
| SMILES | CCCCCCCCCCCCCCO[C@@H]1[C@H]([C@@H]([C@@H](C[N+](C)(C2CCCC2)C)O[C@@H]1OC)O)OCCCCCCCCCCCCCC.[I-] |
Biological Activity
| Description | IAXO-101 iodide is a specific blocker of TLR4/CD14 signaling. This compound effectively inhibits the innate immune pathway mediated by CD14, demonstrating key biological activities such as enhancing intracortical microelectrode recording capabilities in murine models. Additionally, IAXO-101 iodide has been shown to partially alleviate fetal growth restriction and placental vascular damage, while reducing levels of the inflammatory cytokine TNF-α in pregnant mice with malaria infections. It serves as a valuable research tool for studying gestational malaria and other inflammatory disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
