Product Data Sheet
TLR8 agonist 8
Catalog No. A35440
TLR8 Agonist 8 (Compound II-72) acts as a potent agonist for Toll-like receptor 8 (TLR8), exhibiting an effective concentration (EC50) ranging from 0.25 to 1 μM. This compound is stable in both human and murine plasma and stimulates the secretion of cytokine TNFα, with an EC50 of less than 1 μM. Additionally, TLR8 Agonist 8 demonstrates significant antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89% in the MC38-HER2 xenograft mouse model, highlighting its potential for therapeutic applications in oncology and immunotherapy.
Chemical Information
| Catalog Num | A35440 |
|---|---|
| M. Wt | 1014.14 |
| Formula | C53H63N11O10 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3034750-58-5 |
| Synonyms | |
| SMILES | O=C(CNC(CCCCCN1C(C=CC1=O)=O)=O)NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(N3CC4=CC(NC(C5(CC5)C6=CC=C7C(N=C(N)CC(C(N(CCC)CCO)=O)=C7)=C6)=O)=CN=C4CC3)=O)=O)=O |
Biological Activity
| Description | TLR8 Agonist 8 (Compound II-72) acts as a potent agonist for Toll-like receptor 8 (TLR8), exhibiting an effective concentration (EC50) ranging from 0.25 to 1 μM. This compound is stable in both human and murine plasma and stimulates the secretion of cytokine TNFα, with an EC50 of less than 1 μM. Additionally, TLR8 Agonist 8 demonstrates significant antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89% in the MC38-HER2 xenograft mouse model, highlighting its potential for therapeutic applications in oncology and immunotherapy. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
