Product Data Sheet
CRX 527
Catalog No. A35448
CRX 527 is a ligand of Toll-like receptor 4 (TLR4) that functions as an adjuvant for peptide-based cancer vaccines, demonstrating the ability to enhance anti-tumor immune responses. In addition to its immune-modulating properties, CRX 527 induces hematopoietic stem cell (HSC) differentiation, increases the number of Lin⁻Sca-1⁺c-Kit⁺ (LSK) cells, and promotes their differentiation into macrophages. This reagent activates immune defense mechanisms and provides protective effects on intestinal epithelium against radiation damage, making it valuable for cancer immunotherapy and research in regenerative medicine.
Chemical Information
| Catalog Num | A35448 |
|---|---|
| M. Wt | 1488.04 |
| Formula | C81H151N2O19P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 216014-14-1 |
| Synonyms | |
| SMILES | CCCCCCCCCC(O[C@H](CCCCCCCCCCC)CC(O[C@@H]1[C@H]([C@@H](O[C@@H]([C@H]1OP(O)(O)=O)CO)OC[C@@H](C(O)=O)NC(C[C@@H](CCCCCCCCCCC)OC(CCCCCCCCC)=O)=O)NC(C[C@@H](CCCCCCCCCCC)OC(CCCCCCCCC)=O)=O)=O)=O |
Biological Activity
| Description | CRX 527 is a ligand of Toll-like receptor 4 (TLR4) that functions as an adjuvant for peptide-based cancer vaccines, demonstrating the ability to enhance anti-tumor immune responses. In addition to its immune-modulating properties, CRX 527 induces hematopoietic stem cell (HSC) differentiation, increases the number of Lin⁻Sca-1⁺c-Kit⁺ (LSK) cells, and promotes their differentiation into macrophages. This reagent activates immune defense mechanisms and provides protective effects on intestinal epithelium against radiation damage, making it valuable for cancer immunotherapy and research in regenerative medicine. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
