Product Data Sheet
TLR7 antagonist-1
Catalog No. A35457
TLR7 antagonist-1 is a selective antagonist of Toll-like receptor 7 (TLR7), exhibiting an IC50 value of 0.3 nM. It binds specifically to TLR7, inhibiting its activation and subsequently downregulating the c-Rel signaling pathway. This compound effectively reduces the mRNA levels of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α. TLR7 antagonist-1 is particularly relevant for research focused on psoriasis, demonstrating efficacy in alleviating Imiquimod-induced psoriasis-like skin lesions.
Chemical Information
| Catalog Num | A35457 |
|---|---|
| M. Wt | 455.90 |
| Formula | C21H25ClF3N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3104353-70-7 |
| Synonyms | |
| SMILES | CC1=CN(C2=N1)C=C(C=C2OC)C3=CN=C(C(C(F)(F)F)=C3)N4CCC(C)(CC4)N.Cl |
Biological Activity
| Description | TLR7 antagonist-1 is a selective antagonist of Toll-like receptor 7 (TLR7), exhibiting an IC50 value of 0.3 nM. It binds specifically to TLR7, inhibiting its activation and subsequently downregulating the c-Rel signaling pathway. This compound effectively reduces the mRNA levels of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α. TLR7 antagonist-1 is particularly relevant for research focused on psoriasis, demonstrating efficacy in alleviating Imiquimod-induced psoriasis-like skin lesions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
