Product Data Sheet
CRX-526
Catalog No. A35507
CRX-526 is a TLR4 antagonist that inhibits the interaction of lipopolysaccharide (LPS) with immune cells, effectively reducing the expression of pro-inflammatory genes and the release of TNF-α induced by LPS. This compound demonstrates significant anti-inflammatory properties, as evidenced by its efficacy in two distinct mouse models of colitis: the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient model. CRX-526 is a valuable tool for research focused on inflammatory pathways and associated therapeutic interventions.
Chemical Information
| Catalog Num | A35507 |
|---|---|
| M. Wt | 1319.72 |
| Formula | C69H127N2O19P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 245515-64-4 |
| Synonyms | |
| SMILES | O=C([C@H](CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1NC(C[C@@H](CCCCCCCCCCC)OC(CCCCC)=O)=O)OC(C[C@@H](CCCCCCCCCCC)OC(CCCCC)=O)=O)OP(O)(O)=O)CO)NC(C[C@@H](CCCCCCCCCCC)OC(CCCCC)=O)=O)O |
Biological Activity
| Description | CRX-526 is a TLR4 antagonist that inhibits the interaction of lipopolysaccharide (LPS) with immune cells, effectively reducing the expression of pro-inflammatory genes and the release of TNF-α induced by LPS. This compound demonstrates significant anti-inflammatory properties, as evidenced by its efficacy in two distinct mouse models of colitis: the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient model. CRX-526 is a valuable tool for research focused on inflammatory pathways and associated therapeutic interventions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
