Product Data Sheet
Atazanavir-d24
Catalog No. A35516
Atazanavir-d24 is a deuterium-labeled derivative of Atazanavir, which primarily functions as a selective and orally bioavailable HIV-1 protease inhibitor. This compound also exhibits inhibitory effects on CYP3A4 and P-glycoprotein, making it relevant for studies on drug metabolism and transport. Additionally, Atazanavir demonstrates antiviral activity against SARS-CoV 3CLpro with an IC50 of 3.49 μM and has been implicated in the inhibition of cardiac fibrosis and hyperlipidemia, as well as the induction of cell death in malignant glioma. It serves as a valuable research tool for investigating HIV treatment and related pathophysiological mechanisms.
Chemical Information
| Catalog Num | A35516 |
|---|---|
| M. Wt | 729.00 |
| Formula | C38H28D24N6O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1092540-58-3 |
| Synonyms | BMS-232632-d24 |
| SMILES | [2H]C([2H])([2H])OC(N[C@@H](C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(NC([C@H](C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])NC(OC([2H])([2H])[2H])=O)=O)CC2=CC=C(C3=CC=CC=N3)C=C2)=O)=O |
Biological Activity
| Description | Atazanavir-d24 is a deuterium-labeled derivative of Atazanavir, which primarily functions as a selective and orally bioavailable HIV-1 protease inhibitor. This compound also exhibits inhibitory effects on CYP3A4 and P-glycoprotein, making it relevant for studies on drug metabolism and transport. Additionally, Atazanavir demonstrates antiviral activity against SARS-CoV 3CLpro with an IC50 of 3.49 μM and has been implicated in the inhibition of cardiac fibrosis and hyperlipidemia, as well as the induction of cell death in malignant glioma. It serves as a valuable research tool for investigating HIV treatment and related pathophysiological mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
