Product Data Sheet
JT002
Catalog No. A35545
JT002 is a selective inhibitor of the NLRP3 inflammasome assembly. It effectively reduces the production of NLRP3-dependent proinflammatory cytokines, including IL-1β, IL-1α, and IL-18, while also inhibiting pyroptosis. In preclinical studies, JT002 demonstrated the ability to mitigate airway hyperresponsiveness and airway neutrophilia in murine models, making it a valuable tool for investigating various inflammatory diseases, such as Muckle-Wells syndrome.
Chemical Information
| Catalog Num | A35545 |
|---|---|
| M. Wt | 432.49 |
| Formula | C20H24N4O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2238820-43-2 |
| Synonyms | |
| SMILES | O=C(NS(=O)(C1=C(OC[C@@H](OC)C2)N2N=C1)=O)NC3=C(CCC4)C4=CC5=C3CCC5 |
Biological Activity
| Description | JT002 is a selective inhibitor of the NLRP3 inflammasome assembly. It effectively reduces the production of NLRP3-dependent proinflammatory cytokines, including IL-1β, IL-1α, and IL-18, while also inhibiting pyroptosis. In preclinical studies, JT002 demonstrated the ability to mitigate airway hyperresponsiveness and airway neutrophilia in murine models, making it a valuable tool for investigating various inflammatory diseases, such as Muckle-Wells syndrome. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
