Product Data Sheet
YQ128
Catalog No. A35554
YQ128 is a potent and selective second-generation inhibitor of the NLRP3 inflammasome, demonstrating an IC50 value of 0.30 μM. It effectively suppresses the production of interleukin-1 beta (IL-1β) while sparing tumor necrosis factor-alpha (TNF-α), making it a valuable tool in the study of inflammation. Notably, YQ128 can penetrate the blood-brain barrier, allowing for potential applications in central nervous system research. Additionally, YQ128 features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), broadening its utility in click chemistry applications.
Chemical Information
| Catalog Num | A35554 |
|---|---|
| M. Wt | 545.11 |
| Formula | C27H29ClN2O4S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2454246-18-3 |
| Synonyms | |
| SMILES | O=S(C1=CC=C(CCN(CC2=C(C=CC(Cl)=C2)OCCC)C(CC3=CSC=C3)=O)C=C1)(NCC#C)=O |
Biological Activity
| Description | YQ128 is a potent and selective second-generation inhibitor of the NLRP3 inflammasome, demonstrating an IC50 value of 0.30 μM. It effectively suppresses the production of interleukin-1 beta (IL-1β) while sparing tumor necrosis factor-alpha (TNF-α), making it a valuable tool in the study of inflammation. Notably, YQ128 can penetrate the blood-brain barrier, allowing for potential applications in central nervous system research. Additionally, YQ128 features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), broadening its utility in click chemistry applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
