Product Data Sheet
NP3-562
Catalog No. A35555
NP3-562 is a potent, orally active inhibitor of NLRP3, a key component of the inflammasome pathway. It effectively suppresses IL-1β release in Nigericin-stimulated THP-1 cells with an IC50 of 66 nM, and in human whole blood with an IC50 of 214 nM. This compound is valuable for investigating the role of NLRP3 activation in inflammatory conditions, particularly in acute peritonitis models.
Chemical Information
| Catalog Num | A35555 |
|---|---|
| M. Wt | 437.94 |
| Formula | C19H24ClN5O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2409825-32-5 |
| Synonyms | |
| SMILES | CC(O)(C(N1C2=C(SC(Cl)=C2)C=C13)=NN(CC(N[C@H]4CN(CCC4)C)=O)C3=O)C |
Biological Activity
| Description | NP3-562 is a potent, orally active inhibitor of NLRP3, a key component of the inflammasome pathway. It effectively suppresses IL-1β release in Nigericin-stimulated THP-1 cells with an IC50 of 66 nM, and in human whole blood with an IC50 of 214 nM. This compound is valuable for investigating the role of NLRP3 activation in inflammatory conditions, particularly in acute peritonitis models. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
