Product Data Sheet
NLRP3-IN-25
Catalog No. A35572
NLRP3-IN-25 is an orally available NLRP3 inhibitor that exhibits significant anti-inflammatory properties. It effectively reduces renal injury in a doxorubicin-induced glomerulonephritis model in mice. Additionally, NLRP3-IN-25 demonstrates the ability to inhibit IL-1β secretion in THP-1 cells, with an IC50 value of 21 nM, making it a valuable tool for research into NLRP3-related inflammatory conditions.
Chemical Information
| Catalog Num | A35572 |
|---|---|
| M. Wt | 448.42 |
| Formula | C17H19F3N4O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2660230-90-8 |
| Synonyms | |
| SMILES | O=C(C1=COC(NC2=CC(C(F)(F)F)=CC=C2C)=N1)NS(=O)(N3CCOCCC3)=O |
Biological Activity
| Description | NLRP3-IN-25 is an orally available NLRP3 inhibitor that exhibits significant anti-inflammatory properties. It effectively reduces renal injury in a doxorubicin-induced glomerulonephritis model in mice. Additionally, NLRP3-IN-25 demonstrates the ability to inhibit IL-1β secretion in THP-1 cells, with an IC50 value of 21 nM, making it a valuable tool for research into NLRP3-related inflammatory conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
