Product Data Sheet
D359-0396
Catalog No. A35577
D359-0396 is an orally active inhibitor of the NLRP3 inflammasome. This compound effectively inhibits pyroptosis and the release of IL-1β in macrophages by preventing the oligomerization of NLRP3 and ASC, as well as the cleavage of GSDMD. D359-0396 has demonstrated therapeutic potential in experimental autoimmune encephalomyelitis (EAE) and enhances survival rates in murine models of septic shock. This reagent is suitable for research applications focused on inflammation and immune response modulation.
Chemical Information
| Catalog Num | A35577 |
|---|---|
| M. Wt | 400.47 |
| Formula | C24H24N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1031977-31-7 |
| Synonyms | |
| SMILES | O=C1C2=CN3C4=C(NC(C3=C2N(C)C(N1C)=O)C5=CC=C(C(C)C)C=C5)C=CC=C4 |
Biological Activity
| Description | D359-0396 is an orally active inhibitor of the NLRP3 inflammasome. This compound effectively inhibits pyroptosis and the release of IL-1β in macrophages by preventing the oligomerization of NLRP3 and ASC, as well as the cleavage of GSDMD. D359-0396 has demonstrated therapeutic potential in experimental autoimmune encephalomyelitis (EAE) and enhances survival rates in murine models of septic shock. This reagent is suitable for research applications focused on inflammation and immune response modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
