Product Data Sheet
JC-171
Catalog No. A35578
JC-171 is a selective NLRP3 inflammasome inhibitor that demonstrates an IC50 of 8.45 μM in blocking LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages. This compound is valuable for research focused on the roles of NLRP3 in inflammatory diseases, as it allows for the investigation of inflammasome activation and associated cytokine release pathways. Its specificity makes it a useful tool in studying the modulation of innate immune responses in various experimental models.
Chemical Information
| Catalog Num | A35578 |
|---|---|
| M. Wt | 384.83 |
| Formula | C16H17ClN2O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2112809-98-8 |
| Synonyms | |
| SMILES | O=C(NCCC1=CC=C(S(=O)(NO)=O)C=C1)C2=CC(Cl)=CC=C2OC |
Biological Activity
| Description | JC-171 is a selective NLRP3 inflammasome inhibitor that demonstrates an IC50 of 8.45 μM in blocking LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages. This compound is valuable for research focused on the roles of NLRP3 in inflammatory diseases, as it allows for the investigation of inflammasome activation and associated cytokine release pathways. Its specificity makes it a useful tool in studying the modulation of innate immune responses in various experimental models. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
