Product Data Sheet
NLRP3-IN-NBC6
Catalog No. A35584
NLRP3-IN-NBC6 is a selective inhibitor of the NLRP3 inflammasome, exhibiting an IC50 of 574 nM and functioning independently of calcium ions. It effectively inhibits Nigericin-induced inflammasome activation in THP-1 cells and reduces IL-1β release in response to Imiquimod from LPS-primed bone marrow-derived macrophages. This compound is valuable for studying the role of inflammasome activation in various inflammatory diseases and metabolic disorders.
Chemical Information
| Catalog Num | A35584 |
|---|---|
| M. Wt | 409.50 |
| Formula | C18H16BCl3N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2068818-02-8 |
| Synonyms | |
| SMILES | CC(C1=C(N[B-](C2=CC=CC=C2)([O+]=C1N)C3=CC=CC=C3)C(Cl)(Cl)Cl)=O |
Biological Activity
| Description | NLRP3-IN-NBC6 is a selective inhibitor of the NLRP3 inflammasome, exhibiting an IC50 of 574 nM and functioning independently of calcium ions. It effectively inhibits Nigericin-induced inflammasome activation in THP-1 cells and reduces IL-1β release in response to Imiquimod from LPS-primed bone marrow-derived macrophages. This compound is valuable for studying the role of inflammasome activation in various inflammatory diseases and metabolic disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
