Product Data Sheet
IIIM-1266
Catalog No. A35608
IIIM-1266 is a potent NLRP3 inflammasome inhibitor that effectively inhibits the release of IL-1β in mouse macrophages (J774A.1 cells) with an IC50 of 2.3 μM. This compound significantly reduces the protein expression levels of mature IL-1β, making it a valuable tool for studying inflammation and its associated pathways in research settings. IIIM-1266 provides insights into the role of the NLRP3 inflammasome in inflammatory responses and potential therapeutic interventions.
Chemical Information
| Catalog Num | A35608 |
|---|---|
| M. Wt | 306.38 |
| Formula | C15H18N2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2468202-93-7 |
| Synonyms | |
| SMILES | O=S(C1=C2C(C3=CC=C2)C(NC3=O)C=C1)(N(CC)CC)=O |
Biological Activity
| Description | IIIM-1266 is a potent NLRP3 inflammasome inhibitor that effectively inhibits the release of IL-1β in mouse macrophages (J774A.1 cells) with an IC50 of 2.3 μM. This compound significantly reduces the protein expression levels of mature IL-1β, making it a valuable tool for studying inflammation and its associated pathways in research settings. IIIM-1266 provides insights into the role of the NLRP3 inflammasome in inflammatory responses and potential therapeutic interventions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
