Product Data Sheet
NLRP3/URAT1-IN-1
Catalog No. A35613
NLRP3/URAT1-IN-1 is an orally active dual inhibitor targeting NLRP3 and URAT1, with an IC50 of 3.81 μM. This compound effectively inhibits IL-1β release in LPS- and ATP-stimulated mouse bone marrow-derived macrophages, demonstrating an IC50 of 2.61 μM. In vivo studies reveal that NLRP3/URAT1-IN-1 significantly reduces serum uric acid levels and mitigates liver and kidney damage in models of acute hyperuricemia. This reagent is essential for investigating the pathophysiology of gout and hyperuricemia.
Chemical Information
| Catalog Num | A35613 |
|---|---|
| M. Wt | 525.44 |
| Formula | C24H17BrN2O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2994637-53-3 |
| Synonyms | |
| SMILES | O=C(C(N1CC2=C3C=CC=CC3=C(Br)C=C2)=CC4=C1C=CC=C4)NS(=O)(C5=CC=CS5)=O |
Biological Activity
| Description | NLRP3/URAT1-IN-1 is an orally active dual inhibitor targeting NLRP3 and URAT1, with an IC50 of 3.81 μM. This compound effectively inhibits IL-1β release in LPS- and ATP-stimulated mouse bone marrow-derived macrophages, demonstrating an IC50 of 2.61 μM. In vivo studies reveal that NLRP3/URAT1-IN-1 significantly reduces serum uric acid levels and mitigates liver and kidney damage in models of acute hyperuricemia. This reagent is essential for investigating the pathophysiology of gout and hyperuricemia. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
