Product Data Sheet
Apilimod hydrochloride
Catalog No. A35614
Apilimod hydrochloride is an inhibitor of the PIKFYVE kinase, targeting the NOD-like receptor (NLR) pathway. This compound facilitates the activation of NLRP3 inflammatory vesicles and promotes the secretion of IL-1β. Its ability to inhibit host cell proteases may prevent viral invasion; however, it may also obstruct antiviral immune responses, which could lead to increased immunosuppression in conditions such as COVID-19. Research applications include studies on inflammation, immune response regulation, and viral pathogenesis.
Chemical Information
| Catalog Num | A35614 |
|---|---|
| M. Wt | 491.41 |
| Formula | C23H28Cl2N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 870087-37-9 |
| Synonyms | STA 5326 hydrochloride; LAM-002A (free base) hydrochloride; AIT-101 hydrochloride |
| SMILES | CC1=CC=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=CC=CC=N4)=N2)=C1.Cl.Cl |
Biological Activity
| Description | Apilimod hydrochloride is an inhibitor of the PIKFYVE kinase, targeting the NOD-like receptor (NLR) pathway. This compound facilitates the activation of NLRP3 inflammatory vesicles and promotes the secretion of IL-1β. Its ability to inhibit host cell proteases may prevent viral invasion; however, it may also obstruct antiviral immune responses, which could lead to increased immunosuppression in conditions such as COVID-19. Research applications include studies on inflammation, immune response regulation, and viral pathogenesis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
