Product Data Sheet
MC-ND-18
Catalog No. A35615
MC-ND-18 is an ATTEC degrader targeting NLRP3, functioning primarily through autophagic pathways. With a DC50 value of 125.5 nM in THP-1 cells, this compound facilitates the selective degradation of NLRP3. Composed of a ligand specific to NLRP3, a linker, and an LC3 ligand, MC-ND-18 is valuable for research investigating inflammation and diseases associated with NLRP3 activation.
Chemical Information
| Catalog Num | A35615 |
|---|---|
| M. Wt | 1051.58 |
| Formula | C42H42Br2IN3O9S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3081572-53-1 |
| Synonyms | |
| SMILES | IC1=CC=C(C(/C(C2=O)=C/C3=CC(Br)=C(O)C(Br)=C3)=C1)N2CCOCCOCCOCCOC4=CC=C(S(NC(NC5=C6C(CCC6)=CC7=C5CCC7)=O)(=O)=O)C=C4 |
Biological Activity
| Description | MC-ND-18 is an ATTEC degrader targeting NLRP3, functioning primarily through autophagic pathways. With a DC50 value of 125.5 nM in THP-1 cells, this compound facilitates the selective degradation of NLRP3. Composed of a ligand specific to NLRP3, a linker, and an LC3 ligand, MC-ND-18 is valuable for research investigating inflammation and diseases associated with NLRP3 activation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
