Product Data Sheet
NEK7 degrader-2
Catalog No. A35626
NEK7 degrader-2 (Compound 25) is a targeted NEK7 degrader that facilitates dose-dependent degradation of NEK7 specifically in human PBMC-derived macrophages. This compound effectively reduces the release of pro-inflammatory cytokine IL-1β triggered by NLRP3 inflammasome activation. NEK7 degrader-2 serves as a valuable tool for investigating the mechanisms underlying inflammatory diseases.
Chemical Information
| Catalog Num | A35626 |
|---|---|
| M. Wt | 341.40 |
| Formula | C19H23N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3037413-54-7 |
| Synonyms | |
| SMILES | O=C1NC(C(CC1)N2C(C3=CC=C(C4NCCCC4)C=C3C2C)=O)=O |
Biological Activity
| Description | NEK7 degrader-2 (Compound 25) is a targeted NEK7 degrader that facilitates dose-dependent degradation of NEK7 specifically in human PBMC-derived macrophages. This compound effectively reduces the release of pro-inflammatory cytokine IL-1β triggered by NLRP3 inflammasome activation. NEK7 degrader-2 serves as a valuable tool for investigating the mechanisms underlying inflammatory diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
