Product Data Sheet
BMS-986189
Catalog No. A35665
BMS-986189 is a macrocyclic peptide that functions as a highly potent PD-L1 inhibitor, demonstrating an IC50 of 1.03 nM in disrupting the PD-1/PD-L1 interaction. This compound is suitable for cancer research applications, particularly in studies involving human lung carcinoma cells such as L2987, making it valuable for exploring immune checkpoint mechanisms and developing novel therapeutic strategies.
Chemical Information
| Catalog Num | A35665 |
|---|---|
| M. Wt | 1887.21 |
| Formula | C91H131N21O21S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1629665-96-8 |
| Synonyms | |
| SMILES | C(C=1C=2C(N(CC(O)=O)C1)=CC=CC2)[C@H]3C(=O)N(C)[C@@H](CCCC)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(NCC(N)=O)=O)CSCC(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N5[C@](C(=O)N[C@@H](CN)C(=O)N[C@@H](CC(C)C)C(=O)N6[C@](C(=O)N[C@@H](CC=7C=8C(NC7)=CC=CC8)C(=O)N[C@@H](CCN)C(=O)N3)(C[C@@H](O)C6)[H])(CCC5)[H] |
Biological Activity
| Description | BMS-986189 is a macrocyclic peptide that functions as a highly potent PD-L1 inhibitor, demonstrating an IC50 of 1.03 nM in disrupting the PD-1/PD-L1 interaction. This compound is suitable for cancer research applications, particularly in studies involving human lung carcinoma cells such as L2987, making it valuable for exploring immune checkpoint mechanisms and developing novel therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
