Product Data Sheet
CVRARTR
Catalog No. A35676
CVARARTR is a potent antagonist of programmed cell death ligand-1 (PD-L1) with a dissociation constant (KD) of 281 nM. It promotes the internalization of PD-L1, leading to a decrease in its surface expression. This mechanism effectively restores cytokine secretion and enhances T cell proliferation in CT26 cells. Additionally, CVRARTR demonstrates antitumor efficacy in the CT26 homograft mouse model, making it a valuable tool for research in melanoma and immunotherapy studies.
Chemical Information
| Catalog Num | A35676 |
|---|---|
| M. Wt | 861.03 |
| Formula | C33H64N16O9S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2349354-64-7 |
| Synonyms | |
| SMILES | [C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)[C@@H](C)O)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CS)N)=O)C(C)C)=O)CCCNC(=N)N)=O)C)=O)CCCNC(=N)N |
Biological Activity
| Description | CVARARTR is a potent antagonist of programmed cell death ligand-1 (PD-L1) with a dissociation constant (KD) of 281 nM. It promotes the internalization of PD-L1, leading to a decrease in its surface expression. This mechanism effectively restores cytokine secretion and enhances T cell proliferation in CT26 cells. Additionally, CVRARTR demonstrates antitumor efficacy in the CT26 homograft mouse model, making it a valuable tool for research in melanoma and immunotherapy studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
