Product Data Sheet
BMS-37
Catalog No. A35690
BMS-37 is a potent PD-1/PD-L1 immune checkpoint inhibitor, demonstrating an IC50 ranging from 18 to 200 nM against the PD-L1/PD-1 complex. This compound exhibits significant toxicity toward modified Jurkat T cells, with an EC50 between 3 and 6 µM. BMS-37 is valuable for investigating PD-L1-mediated T-cell exhaustion and serves as a PD-L1 ligand in the synthesis of PROTAC molecules for targeted protein degradation studies.
Chemical Information
| Catalog Num | A35690 |
|---|---|
| M. Wt | 448.55 |
| Formula | C27H32N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1675202-20-6 |
| Synonyms | |
| SMILES | COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCNC(C)=O |
Biological Activity
| Description | BMS-37 is a potent PD-1/PD-L1 immune checkpoint inhibitor, demonstrating an IC50 ranging from 18 to 200 nM against the PD-L1/PD-1 complex. This compound exhibits significant toxicity toward modified Jurkat T cells, with an EC50 between 3 and 6 µM. BMS-37 is valuable for investigating PD-L1-mediated T-cell exhaustion and serves as a PD-L1 ligand in the synthesis of PROTAC molecules for targeted protein degradation studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
