Product Data Sheet
LP23
Catalog No. A35721
LP23 is a potent non-arylmethylamine inhibitor of the PD-1/PD-L1 axis, exhibiting an IC50 of 16.7 nM. It effectively restores immune cell function in HepG2 and Jurkat T cell assays and promotes cell death in HepG2 cancer cells. In vivo studies demonstrate its significant anti-tumor activity in the B16-F10 tumor model, achieving a tumor growth inhibition of 88.6% at a dose of 30 mg/kg. This compound serves as a valuable tool for cancer immunotherapy research and the investigation of immune checkpoint pathways.
Chemical Information
| Catalog Num | A35721 |
|---|---|
| M. Wt | 505.59 |
| Formula | C27H27N3O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3008239-25-3 |
| Synonyms | |
| SMILES | O=C([C@@H](NCC1=CC(CSC2=NN=C(COC3=C(C)C(C4=CC=CC=C4)=CC=C3)O2)=CC=C1)CO)O |
Biological Activity
| Description | LP23 is a potent non-arylmethylamine inhibitor of the PD-1/PD-L1 axis, exhibiting an IC50 of 16.7 nM. It effectively restores immune cell function in HepG2 and Jurkat T cell assays and promotes cell death in HepG2 cancer cells. In vivo studies demonstrate its significant anti-tumor activity in the B16-F10 tumor model, achieving a tumor growth inhibition of 88.6% at a dose of 30 mg/kg. This compound serves as a valuable tool for cancer immunotherapy research and the investigation of immune checkpoint pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
