Product Data Sheet
Lipoxin A4
Catalog No. A35798
Lipoxin A4 (LXA4) is an endogenous eicosanoid mediator with significant anti-inflammatory and pro-resolving activity. It modulates inflammatory responses by inhibiting proliferation and cytokine/chemokine production in human epidermal keratinocytes through the ERK1/2 and NF-kB signaling pathways. Additionally, Lipoxin A4 effectively reduces serum amyloid A (SAA)-induced IL-8 release, demonstrating an IC50 of 25.74 nM. This compound serves as a valuable tool for research in inflammation and resolution processes.
Chemical Information
| Catalog Num | A35798 |
|---|---|
| M. Wt | 352.47 |
| Formula | C20H32O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 89663-86-5 |
| Synonyms | LXA4 |
| SMILES | CCCCC[C@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCC(O)=O |
Biological Activity
| Description | Lipoxin A4 (LXA4) is an endogenous eicosanoid mediator with significant anti-inflammatory and pro-resolving activity. It modulates inflammatory responses by inhibiting proliferation and cytokine/chemokine production in human epidermal keratinocytes through the ERK1/2 and NF-kB signaling pathways. Additionally, Lipoxin A4 effectively reduces serum amyloid A (SAA)-induced IL-8 release, demonstrating an IC50 of 25.74 nM. This compound serves as a valuable tool for research in inflammation and resolution processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
