Product Data Sheet
Oroxylin A-7-O-glucuronide
Catalog No. A35838
Oroxylin A-7-O-glucuronide is a flavonoid glucuronide derivative and metabolite of Oroxylin A, primarily known for its prolyl oligopeptidase inhibitory activity. This compound demonstrates the ability to inhibit the JNK signaling pathway, upregulate PPARγ, and prevent nuclear translocation of NF-κB p65, leading to reduced production of pro-inflammatory cytokines such as IL-1β and IL-6. Additionally, Oroxylin A-7-O-glucuronide exhibits promising anti-angiogenic, anti-tumor, anti-inflammatory, and hepatoprotective properties, making it a valuable tool in cancer research and inflammatory disease studies.
Chemical Information
| Catalog Num | A35838 |
|---|---|
| M. Wt | 460.39 |
| Formula | C22H20O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 36948-76-2 |
| Synonyms | Oroxyloside; Oroxylin A-7-O-β-D-glucuronide |
| SMILES | OC1=C2C(OC(C3=CC=CC=C3)=CC2=O)=CC(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)=C1OC |
Biological Activity
| Description | Oroxylin A-7-O-glucuronide is a flavonoid glucuronide derivative and metabolite of Oroxylin A, primarily known for its prolyl oligopeptidase inhibitory activity. This compound demonstrates the ability to inhibit the JNK signaling pathway, upregulate PPARγ, and prevent nuclear translocation of NF-κB p65, leading to reduced production of pro-inflammatory cytokines such as IL-1β and IL-6. Additionally, Oroxylin A-7-O-glucuronide exhibits promising anti-angiogenic, anti-tumor, anti-inflammatory, and hepatoprotective properties, making it a valuable tool in cancer research and inflammatory disease studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
