Product Data Sheet
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
Catalog No. A35907
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a biased agonist targeting neuropeptide and chemokine receptors, specifically activating the G12 pathway. This compound binds to IL-8 and GRP receptors, resulting in the inhibition of ERK-2 activation while simultaneously promoting JNK activity. It is known to enhance neutrophil migration and calcium mobilization, contributing to its utility in inflammation research. Additionally, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acts as a bombesin antagonist and has demonstrated potential in inhibiting the growth of small cell lung cancer.
Chemical Information
| Catalog Num | A35907 |
|---|---|
| M. Wt | 1516.83 |
| Formula | C79H109N19O12 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 96736-12-8 |
| Synonyms | |
| SMILES | C([C@H](C(N[C@H](C(N[C@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)NC([C@@H](NC([C@H](NC(=O)[C@H]4N(C([C@@H](NC(=O)[C@H]5N(C([C@@H](CCCNC(=N)N)N)=O)CCC5)CCCCN)=O)CCC4)CC6=CC=CC=C6)=O)CCC(N)=O)=O)C=7C=8C(NC7)=CC=CC8 |
Biological Activity
| Description | [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a biased agonist targeting neuropeptide and chemokine receptors, specifically activating the G12 pathway. This compound binds to IL-8 and GRP receptors, resulting in the inhibition of ERK-2 activation while simultaneously promoting JNK activity. It is known to enhance neutrophil migration and calcium mobilization, contributing to its utility in inflammation research. Additionally, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acts as a bombesin antagonist and has demonstrated potential in inhibiting the growth of small cell lung cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
