Product Data Sheet
FKK6
Catalog No. A35925
FKK6 is a selective agonist of the pregnane X receptor (PXR) with an EC50 value of 1.2 µM. This compound demonstrates strong binding affinity to plasma proteins and favorable metabolic stability in human microsomes. FKK6 effectively inhibits the PXR-related NF-κB signaling pathway, reduces the expression of inflammatory cytokines, and displays anti-inflammatory properties in a mouse model of DSS-induced colitis, making it a valuable tool for studies in inflammation and drug metabolism.
Chemical Information
| Catalog Num | A35925 |
|---|---|
| M. Wt | 402.47 |
| Formula | C23H18N2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2238839-34-2 |
| Synonyms | |
| SMILES | C#CCC(O)(C1=CC=NC=C1)C2=CC3=CC=CC=C3N2S(=O)(C4=CC=CC=C4)=O |
Biological Activity
| Description | FKK6 is a selective agonist of the pregnane X receptor (PXR) with an EC50 value of 1.2 µM. This compound demonstrates strong binding affinity to plasma proteins and favorable metabolic stability in human microsomes. FKK6 effectively inhibits the PXR-related NF-κB signaling pathway, reduces the expression of inflammatory cytokines, and displays anti-inflammatory properties in a mouse model of DSS-induced colitis, making it a valuable tool for studies in inflammation and drug metabolism. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
