Product Data Sheet
Hydrocortisone hemisuccinate hydrate
Catalog No. A35948
Hydrocortisone hemisuccinate hydrate serves as an orally active glucocorticoid anti-inflammatory agent, primarily targeting and inhibiting pro-inflammatory cytokines such as IL-6 and IL-3 with IC50 values of 6.7 μM and 21.4 μM, respectively. This compound exhibits significant anti-inflammatory and immunomodulatory activities, making it valuable in research applications related to ulcerative colitis and recurrent oral ulcers. Its ability to modulate inflammation positions it as a key reagent for studies in inflammatory disease pathways.
Chemical Information
| Catalog Num | A35948 |
|---|---|
| M. Wt | 480.55 |
| Formula | C25H36O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 83784-20-7 |
| Synonyms | Hydrocortisone 21-hemisuccinate hydrate |
| SMILES | C[C@@]12[C@](CC[C@]2(O)C(COC(CCC(O)=O)=O)=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])[C@H](C1)O.O |
Biological Activity
| Description | Hydrocortisone hemisuccinate hydrate serves as an orally active glucocorticoid anti-inflammatory agent, primarily targeting and inhibiting pro-inflammatory cytokines such as IL-6 and IL-3 with IC50 values of 6.7 μM and 21.4 μM, respectively. This compound exhibits significant anti-inflammatory and immunomodulatory activities, making it valuable in research applications related to ulcerative colitis and recurrent oral ulcers. Its ability to modulate inflammation positions it as a key reagent for studies in inflammatory disease pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
