Product Data Sheet
Lithocholic amide-C2-N(didecane)
Catalog No. A36059
Lithocholic amide-C2-N(didecane) is a derivative of lithocholic acid designed as an anti-inflammatory agent. This compound exhibits the ability to spontaneously form lipid nanoparticles in aqueous environments, facilitating skin penetration and targeting deeper dermal layers. It demonstrates significant anti-inflammatory activity against psoriasis-like chronic skin conditions by inhibiting keratinocyte proliferation, downregulating mRNA expression of the EphA2 receptor, and reducing serum levels of pro-inflammatory cytokines, including IL-1α, IL-1β, and IFN-γ, through modulation of the Th17/Th2 inflammatory pathway. This makes Lithocholic amide-C2-N(didecane) a valuable tool for researching inflammatory skin disorders.
Chemical Information
| Catalog Num | A36059 |
|---|---|
| M. Wt | 699.19 |
| Formula | C46H86N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2768690-22-6 |
| Synonyms | |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCCN(CCCCCCCCCC)CCCCCCCCCC)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C |
Biological Activity
| Description | Lithocholic amide-C2-N(didecane) is a derivative of lithocholic acid designed as an anti-inflammatory agent. This compound exhibits the ability to spontaneously form lipid nanoparticles in aqueous environments, facilitating skin penetration and targeting deeper dermal layers. It demonstrates significant anti-inflammatory activity against psoriasis-like chronic skin conditions by inhibiting keratinocyte proliferation, downregulating mRNA expression of the EphA2 receptor, and reducing serum levels of pro-inflammatory cytokines, including IL-1α, IL-1β, and IFN-γ, through modulation of the Th17/Th2 inflammatory pathway. This makes Lithocholic amide-C2-N(didecane) a valuable tool for researching inflammatory skin disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
