Product Data Sheet
Isostrictiniin
Catalog No. A36080
Isostrictiniin is a polyphenolic compound derived from Nymphaea candida, functioning as an anti-inflammatory and hepatoprotective agent. It enhances the expression of Nrf2 and HO-1 while inhibiting Keap1, leading to the reduction of phosphorylation levels of key proteins such as JNK, ERK1/2, p38, IκBα, and NF-κB p65. Isostrictiniin effectively decreases pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, and PGE2, demonstrating protective effects against acute lung injury induced by LPS and acute alcoholic liver injury. Its multifaceted activities encompass anti-inflammatory, antioxidant, and anti-fibrotic properties, making it a valuable tool in biochemical research.
Chemical Information
| Catalog Num | A36080 |
|---|---|
| M. Wt | 634.45 |
| Formula | C27H22O18 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1801746-41-7 |
| Synonyms | ITN |
| SMILES | OC1=C2C3=C(O)C(O)=C(O)C=C3C(O[C@]4([H])[C@@]([C@@H]([C@H](O[C@H]4OC(C5=CC(O)=C(C(O)=C5)O)=O)CO)O)([H])OC(C2=CC(O)=C1O)=O)=O |
Biological Activity
| Description | Isostrictiniin is a polyphenolic compound derived from Nymphaea candida, functioning as an anti-inflammatory and hepatoprotective agent. It enhances the expression of Nrf2 and HO-1 while inhibiting Keap1, leading to the reduction of phosphorylation levels of key proteins such as JNK, ERK1/2, p38, IκBα, and NF-κB p65. Isostrictiniin effectively decreases pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, and PGE2, demonstrating protective effects against acute lung injury induced by LPS and acute alcoholic liver injury. Its multifaceted activities encompass anti-inflammatory, antioxidant, and anti-fibrotic properties, making it a valuable tool in biochemical research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
