Product Data Sheet
S217879
Catalog No. A36098
S217879 is a selective NRF2 activator that functions by disrupting the KEAP1-NRF2 interaction with a dissociation constant (Kd) of 4.15 nM. This compound activates the NRF2 pathway, leading to enhanced antioxidant responses. S217879 has demonstrated efficacy in ameliorating steatohepatitis and mitigating liver fibrosis. It is a valuable tool for research focused on metabolic dysfunction-associated steatotic liver disease and nonalcoholic steatohepatitis.
Chemical Information
| Catalog Num | A36098 |
|---|---|
| M. Wt | 592.66 |
| Formula | C30H32N4O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2700303-28-0 |
| Synonyms | |
| SMILES | CC1=CC=C(C=C1[C@H](N2C3)C)[C@H](CC(O)=O)C4=CC=C5C(N=NN5CCOCCOC6=CC3=C(OS2(=O)=O)C=C6)=C4C |
Biological Activity
| Description | S217879 is a selective NRF2 activator that functions by disrupting the KEAP1-NRF2 interaction with a dissociation constant (Kd) of 4.15 nM. This compound activates the NRF2 pathway, leading to enhanced antioxidant responses. S217879 has demonstrated efficacy in ameliorating steatohepatitis and mitigating liver fibrosis. It is a valuable tool for research focused on metabolic dysfunction-associated steatotic liver disease and nonalcoholic steatohepatitis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
