Product Data Sheet
PPADS
Catalog No. A36123
PPADS is a reversible competitive antagonist of P2X receptors, specifically targeting P2X1 and P2X3, with IC50 values of 68 nM and 214 nM, respectively. It demonstrates significant anti-nociceptive effects in mouse models of neuropathic pain and inhibits pro-inflammatory cytokines such as IL-1β and IL-6, as well as nitric oxide synthases. Additionally, PPADS effectively blocks ATP-mediated inward currents in recombinant rat P2X receptors and reduces contractions in rabbit bladder detrusor muscle induced by purinergic nerve stimulation. This compound is valuable for research on neuropathic pain mechanisms and related therapeutic interventions.
Chemical Information
| Catalog Num | A36123 |
|---|---|
| M. Wt | 511.38 |
| Formula | C14H14N3O12PS2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 149017-66-3 |
| Synonyms | |
| SMILES | O=CC1=C(C(C)=NC(/N=N/C2=CC=C(S(=O)(O)=O)C=C2S(=O)(O)=O)=C1COP(O)(O)=O)O |
Biological Activity
| Description | PPADS is a reversible competitive antagonist of P2X receptors, specifically targeting P2X1 and P2X3, with IC50 values of 68 nM and 214 nM, respectively. It demonstrates significant anti-nociceptive effects in mouse models of neuropathic pain and inhibits pro-inflammatory cytokines such as IL-1β and IL-6, as well as nitric oxide synthases. Additionally, PPADS effectively blocks ATP-mediated inward currents in recombinant rat P2X receptors and reduces contractions in rabbit bladder detrusor muscle induced by purinergic nerve stimulation. This compound is valuable for research on neuropathic pain mechanisms and related therapeutic interventions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
