Product Data Sheet
1,11b-Dihydro-11b-hydroxymedicarpin
Catalog No. A36158
1,11b-Dihydro-11b-hydroxymedicarpin is a pterocarpan derivative known for its anti-inflammatory properties. This compound exerts its biological activity by activating the Notch and Wnt canonical signaling pathways, promoting bone healing and mitigating the effects of arthritis. In preclinical models, it inhibits the expansion of TH17 cells and reduces pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17A, while simultaneously enhancing the anti-inflammatory cytokine IL-10. These characteristics make it a valuable reagent for research applications focused on inflammatory diseases and bone regeneration.
Chemical Information
| Catalog Num | A36158 |
|---|---|
| M. Wt | 288.30 |
| Formula | C16H16O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 210537-04-5 |
| Synonyms | 11b-Hydroxy-11b,1-dihydromedicarpin |
| SMILES | O=C(CC1)C=C2[C@@]1(O)[C@@](OC3=CC(OC)=CC=C34)([H])[C@@]4([H])CO2 |
Biological Activity
| Description | 1,11b-Dihydro-11b-hydroxymedicarpin is a pterocarpan derivative known for its anti-inflammatory properties. This compound exerts its biological activity by activating the Notch and Wnt canonical signaling pathways, promoting bone healing and mitigating the effects of arthritis. In preclinical models, it inhibits the expansion of TH17 cells and reduces pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17A, while simultaneously enhancing the anti-inflammatory cytokine IL-10. These characteristics make it a valuable reagent for research applications focused on inflammatory diseases and bone regeneration. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
