Product Data Sheet
Quercetagitrin
Catalog No. A36196
Quercetagitrin, a flavone glycoside, is derived from the African marigold (Tagetes erecta) and exhibits notable anti-inflammatory properties. It effectively inhibits Tau accumulation, reversing neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse models by suppressing NF-κB activation. Additionally, Quercetagitrin acts as a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). This compound enhances glucose uptake in mature C2C12 myoblasts, making it relevant for studies related to Alzheimer’s disease and type 2 diabetes.
Chemical Information
| Catalog Num | A36196 |
|---|---|
| M. Wt | 480.38 |
| Formula | C21H20O13 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 548-75-4 |
| Synonyms | Quercetagetin-7-O-glucoside |
| SMILES | O=C1C2=C(O)C(O)=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2OC(C4=CC(O)=C(O)C=C4)=C1O |
Biological Activity
| Description | Quercetagitrin, a flavone glycoside, is derived from the African marigold (Tagetes erecta) and exhibits notable anti-inflammatory properties. It effectively inhibits Tau accumulation, reversing neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse models by suppressing NF-κB activation. Additionally, Quercetagitrin acts as a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). This compound enhances glucose uptake in mature C2C12 myoblasts, making it relevant for studies related to Alzheimer’s disease and type 2 diabetes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
