Product Data Sheet
KT-333
Catalog No. A36478
KT-333 is a selective STAT3 degrader that induces the degradation of the STAT3 protein via the ubiquitin-proteasome pathway. This compound binds to STAT3 and the E3 ubiquitin ligase von Hippel-Lindau (VHL), facilitating targeted protein degradation. KT-333 has demonstrated significant antitumor activity and is particularly relevant for research in hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL).
Chemical Information
| Catalog Num | A36478 |
|---|---|
| M. Wt | 1257.78 |
| Formula | C60H74ClN10O14PS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2502186-79-8 |
| Synonyms | |
| SMILES | O=C([C@H]1N(C([C@H](C2)NC(C3=CC4=CC(C([P](O)(O)=O)=O)=CC=C4N3)=O)=O)[C@](CCN2C(C)=O)([H])CC1)N[C@@H](CCC(N)=O)COC(C=CC=C5CCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H]6O)[C@@H](C6)C(N[C@H](C7=CC=C(C(SC=N8)=C8C)C=C7)C)=O)=O)=O)=C5Cl |
Biological Activity
| Description | KT-333 is a selective STAT3 degrader that induces the degradation of the STAT3 protein via the ubiquitin-proteasome pathway. This compound binds to STAT3 and the E3 ubiquitin ligase von Hippel-Lindau (VHL), facilitating targeted protein degradation. KT-333 has demonstrated significant antitumor activity and is particularly relevant for research in hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL). |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
